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When your gut bacteria run out of fiber, they may start eating your gut lining

Scientists have identified a mechanism by which gut bacteria deprived of dietary fiber may begin consuming the protective mucus lining of the intestines, p...

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Scientists have identified a mechanism by which gut bacteria deprived of dietary fiber may begin consuming the protective mucus lining of the intestines, potentially releasing harmful compounds in the process. The findings, reported in the health category, suggest that when fermentable fiber is scarce, certain microbial populations shift their metabolism toward mucus glycoproteins as an alternative energy source, a process that can weaken the intestinal barrier. Researchers emphasize that adequate fiber intake helps keep this activity in check, preserving the mucosal layer that shields the gut from inflammation and infection.

The research also highlights overlooked proteins found in plant foods, which appear to help steer gut bacteria toward producing beneficial substances rather than degrading the protective lining. This dual role of plant-based foods, supplying both fiber and specific proteins that influence microbial behavior, offers a surprising new explanation for why plant-rich diets are associated with better digestive and metabolic health. The authors caution that the findings are preliminary and call for further human studies, but say the results reinforce existing public health guidance to increase fiber consumption and plant food variety.

Independent reporting synthesized from primary wires and global correspondents.