Scientists at the University of Southern California have reported that an experimental drug reversed signs of aging in liver cells of rats, sharply reducing levels of a protein linked to Alzheimer’s disease and lowering so-called bad cholesterol to youthful levels. According to the research team, the treatment restored the function of aging liver cells and revived a previously unknown communication system that helps the organ clear harmful substances from the bloodstream. The findings, described as surprising by the investigators, suggest that rejuvenating the liver may offer protection against both Alzheimer’s disease and heart disease.
The discovery points to the liver as a potentially important target in efforts to counter age-related cognitive and cardiovascular decline, though the results come from animal studies and require confirmation in human trials. Researchers cautioned that the mechanism behind the apparent benefits, including the newly identified cellular communication pathway, is not yet fully understood. Independent experts not involved in the work said the findings were promising but preliminary, and that questions remain about the drug’s safety, dosing, and long-term effects. Further studies are expected to examine whether similar results can be reproduced in larger animals and, eventually, in people.
Independent reporting synthesized from primary wires and global correspondents.