Scientists have identified a potential clue to autism's origins in the placenta, according to research examining inflammation during pregnancy. The study found that induced inflammation in pregnant mice led to placental damage and the development of autism-like traits in their male offspring. Notably, female offspring appeared naturally protected from these effects, a finding that may help explain why autism is diagnosed more frequently in boys than girls. The research adds to growing evidence linking prenatal environmental factors to neurodevelopmental outcomes.
The findings, while based on animal models, suggest new avenues for early intervention. Researchers say the sex-specific protection observed in females warrants further investigation, as understanding the mechanisms behind this resilience could inform preventive strategies. Experts caution that the mouse study does not establish a direct causal pathway in humans, and clinical validation is needed. Still, the placental connection offers a promising direction for identifying at-risk pregnancies earlier and potentially mitigating developmental risks before symptoms emerge.
Independent reporting synthesized from primary wires and global correspondents.